Description
Ultrarapid freezing has long been recognised as the go to method to provide preservation of ultrastructure, localisation of soluble inorganic and organic species, and preservation of antigenicity. Ultrarapid freezing can provide results that are superior to that obtainable through conventional chemical fixation techniques and the use of cryoprotectants. Furthermore, it is the only procedure currently available for capturing events that occur on timescales less than a few seconds.
Uses / Applications
Cryo-fixation of isolated or assembled macromolecules
Cryo-fixation of emulsions paints and polymers
Cryo-fixation of suspension and tissues for Cryo-techniques such as freeze fracture/etch, freeze drying, freeze substitution.
